The 5-year-old broke medical records, and his life was in danger several times. The "miracle boy" was finally rescued

time:2022-12-09 11:14:44source:monlittlebaby.com author:Baby bones
The 5-year-old broke medical records, and his life was in danger several times. The "miracle boy" was finally rescued

*For medical professionals only, he won the hearts of the people of the country Oscar (Oscar Saxelby Lee) broke the "British record" twice in one year, and was called "the miracle boy" by the media. In early 2019, more than 6,200 people donated blood and signed letters of intent to donate hematopoietic stem cells for him. This is a new record for such donations in the UK. On March 3, 2019, thousands of people rushed to Worcester from all over the UK, queuing in the rain, hoping to register and donate hematopoietic stem cells to Oscar. /SWNS At the end of the same year, due to the development of the disease, he went overseas to seek medical treatment and received CAR-T treatment. Before him, no children with similar conditions in the UK had been treated with this type of treatment, and there were only a few cases in the world. As of this writing, Oscar has been "cancer-free" for 2 1/2 years. His mother Olivia Saxelby is grateful: "Thank you to everyone who supported the Oscars. Without you, we wouldn't be where we are today." Oscar Saxelby Lee, March 2022. /worcesternews2018, Oscar is 4 years old. Parents find that their active son "has changed". Often sluggish, do not like to move. There will always be bruises on the body inexplicably. Appetite is getting worse and worse, and you will be full after two bites. On Christmas Eve that year, Oscar was diagnosed with acute lymphoblastic leukemia (ALL). Oscar and his parents before the illness. /SWNS This is a hematological malignancy that can account for more than 70% of childhood leukemias. The peak incidence is during childhood. Combination chemotherapy is the basic treatment for ALL. According to some data, this can effectively cure 80% of patients. Oscar is that 20%. The picture comes from the BBC. As of March 2019, he had 20 blood transfusions and completed 4 courses of chemotherapy. But the condition is not optimistic. The Birmingham Children's Hospital in England, which treated him, said the cancer was still spreading rapidly and Oscar needed a hematopoietic stem cell transplant. "As soon as possible. Time window to find a donor, or just 3 months." "We're in a race against time," said DKMS, a charity working on blood cancer aid programs. Agency spokeswoman Sarah Gray said finding a match was very difficult, like winning the lottery. But the more people who sign up, the higher the matchmaking success rate. At that time, Oscar had just started school. His school, Pitmaston Primary School, learned of the incident and decided to hold a "blood donation matching event" for him. The principal of Worcester Elementary School was interviewed by the media. The projection screen behind her reads: "How many friends can you have today?" / BBC School joined hands with DKMS to transform the indoor sports field, auditorium, etc. into a "registration center". With the assistance of 80 volunteers, within 2 hours, more than 300 people came to register and complete the collection of saliva samples. These people also donated blood for Oscar on the spot. Image sourced from the SWNS campaign that lasted 2 days. During the same period, Worcester City Hall and the University of Worcester also put up posters "Help Oscar". Over 1,000 people came to register and sample. Post-mortem statistics show that a total of 6,200 people were recruited to register and donate blood in this public welfare activity. "We have done similar charity events. At the peak of the number of participants, it was 2200 people. This time the number of participants tripled, and they came from all over the UK." DKMS said, "This little boy has won the hearts of people across the country." From DKMS On March 29, 2019, Oscar's mother officially announced "good news" on social media: "3 people have been paired successfully! This greatly increases Oscar's chances of survival." It's not just Oscar who benefited from this event . DKMS found that as of the spring of 2020, another 5 blood cancer patients had found a matching donor among the above-mentioned more than 1,000 kind people and completed the transplant. Worcester Elementary School will collect saliva samples and send them to designated laboratories for DNA testing. Nearly 2 months after the end of the /SWNS activities, Oscar completed the hematopoietic stem cell transplantation. The good times don't last long. Three months after surgery, doctors detected cancer cells in his bone marrow. After a week, the number of cancer cells nearly tripled. Doctors believe that traditional treatment is not very effective, and may be able to give CAR-T a shot. This is a cellular immunotherapy. Doctors will extract T cells, immune cells with powerful fighting ability, from Oscar, and perform genetic modification in vitro, modify genetic material, and introduce activatable molecules that can accurately identify tumor cells. Next, the "edited" cells are cultured. After multiplying enough, it is returned to Oscar to kill the cancer cells in his body. During the hospitalization, Oscar participated in classroom activities through the robot "Ozzybot". The robot can capture Oscar's demeanor, making happy, confused or sad looks at the terminal. /Daily Mail On November 27, 2018, Great Ormond Street Children's Hospital in the United Kingdom was approved by the National Health Service (NHS) to carry out CAR-T treatment. Related therapies are available for relapsed or refractory B-cell ALL under the age of 25. Oscar falls under relapsed T-cell ALL and is not covered by the NHS mandate. Therefore, he was unable to receive related treatment in the UK. Mother Olivia searched the Internet and found that scholars from the National University of Singapore Hospital had published relevant papers. After getting in touch with the hospital, Olivia learned that the treatment is "compassionate treatment" in Singapore, and there is only one case of treatment experience for a similar child. Moreover, it costs 500,000 pounds (about 4.02 million yuan) - the NHS said that it will not pay for overseas medical treatment. After the illness, Oscar often had bruises on his body. /CNA "The only hope for survival is to go to Singapore to complete CAR-T treatment. We need everyone's support and goodwill so that Oscar can enter the next stage of treatment." Oscar's parents launched online crowdfunding, "Our situation is really Terrible." Millions of people gave generously. Schools and enterprises at all levels in Worcester set up "Oscar Fundraising Day" to take to the streets to raise funds for children. With the help of a local foundation dedicated to children's oncology research, in just 3 weeks, the treatment fee was collected. Nonprofits make posters for fundraising. During the /Mirror fundraising period, Birmingham Children's Hospital in the UK gave Oscar a second hematopoietic stem cell transplant. Post-operatively, he will have a short window period during which he can recover to a certain extent to complete the long journey. Picture from Mirror In November 2019, Oscar and his family arrived in Singapore. At this time, the little boy was thin to pieces of paper, unable to stand or walk. The treatment process was very uneventful. He had severe side effects including vomiting, diarrhea, brain damage, and repeated syncope. The doctor constantly adjusted the medication to help him survive the treatment and reduce adverse reactions. The time travels to January and April of the following year. Two tests showed that no cancer cells were detected in Oscar's body. CAR-T works. By the spring of 2020, Oscar was out of the hospital. Before leaving, the National University Hospital of Singapore collected his blood to collect immune cells and cryopreserved them as a backup resource for Oscar's follow-up treatment. In May 2020, Oscar was discharged from the Singapore National University Hospital. /Daily Mail After returning to the UK, Oscar underwent months of rehabilitation. During the winter, he returned to school and learned to play football again. The following spring, he would practice basketball one night a week. As of the publication of this article, Oscar's re-examination results are all good, and no signs of cancer cells are found. "He's thinner and weaker than his peers. But we're very relieved to see him working hard and better than the day before," Oscar's parents said. "It's not just about curing cancer. More importantly, we haven't given up." Image source: 1.Oscar Saxelby-Lee: Family celebrates one year since boy's cancer care. BBC2.Oscar Saxelby-Lee faces more heartbreak over struggle for Australia holiday. Worcester News 3. Boy, 5, with rare cancer faced 'life or death' three month race against time. The Mirror4.5-year-old battling cancer finds perfect stem cell donor match after over 10,000 people come forward to help. MEAWW5.Record 4,855 people queue in the rain for HOURS to see if they are a stem cell match for boy, five, battling rare cancer after his parents launch desperate plea in hope of saving his life. Daily Mail Source of this article: The author of this article in the medical world: Yan Xiaoliu Editor in charge: Xiang Yu, the pediatric clinical knowledge doctor station app you want to see 👇 1. Scan the QR code below 2. 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